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p stat1  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc p stat1
    (A) Schematic of TAM extraction from murine TNBC tumors. (B) Flow cytometry analysis gating strategy comparing CXCL9 protein abundance captured in the media. (C) Flow cytometry analysis gating for CD11b+F4/80+ cells after culture. (D) Bar plots summarize flow cytometry across replicates for CXCL9 abundance in media (T-test, p < 0.001, n=3, SEM bars) (E) Bar plots summarize flow cytometry across replicates for CXCL9 and iNOS within TAMs. (One way ANOVA, p < 0.001 for all comparisons, n=6, SEM bars) (F) Schematic of TAM expression of markers after reprogramming. (G) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in 2153L TAMs. (H) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in T12 TAMs. (I) Dot plot for Day 7 scRNAseq dataset showing <t>STAT1</t> and SOCS1 expression enriched in the CXCL9+ Mo.Mac population. Created in BioRender. Zhao, N. (2026) https://BioRender.com/e6uqj0s .
    P Stat1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho+stat1+tyr701/Phospho-Stat1+(Tyr701)+Rabbit+mAb/pmc13584615-100-51-52
    Average 94 stars, based on 16 article reviews
    p stat1 - by Bioz Stars, 2026-10
    94/100 stars

    Images

    1) Product Images from "MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9 + monocyte-macrophage programming and durable antitumor immunity in triple negative breast cancer"

    Article Title: MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9 + monocyte-macrophage programming and durable antitumor immunity in triple negative breast cancer

    Journal: Cancer immunology research

    doi: 10.1158/2326-6066.CIR-26-0278

    (A) Schematic of TAM extraction from murine TNBC tumors. (B) Flow cytometry analysis gating strategy comparing CXCL9 protein abundance captured in the media. (C) Flow cytometry analysis gating for CD11b+F4/80+ cells after culture. (D) Bar plots summarize flow cytometry across replicates for CXCL9 abundance in media (T-test, p < 0.001, n=3, SEM bars) (E) Bar plots summarize flow cytometry across replicates for CXCL9 and iNOS within TAMs. (One way ANOVA, p < 0.001 for all comparisons, n=6, SEM bars) (F) Schematic of TAM expression of markers after reprogramming. (G) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in 2153L TAMs. (H) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in T12 TAMs. (I) Dot plot for Day 7 scRNAseq dataset showing STAT1 and SOCS1 expression enriched in the CXCL9+ Mo.Mac population. Created in BioRender. Zhao, N. (2026) https://BioRender.com/e6uqj0s .
    Figure Legend Snippet: (A) Schematic of TAM extraction from murine TNBC tumors. (B) Flow cytometry analysis gating strategy comparing CXCL9 protein abundance captured in the media. (C) Flow cytometry analysis gating for CD11b+F4/80+ cells after culture. (D) Bar plots summarize flow cytometry across replicates for CXCL9 abundance in media (T-test, p < 0.001, n=3, SEM bars) (E) Bar plots summarize flow cytometry across replicates for CXCL9 and iNOS within TAMs. (One way ANOVA, p < 0.001 for all comparisons, n=6, SEM bars) (F) Schematic of TAM expression of markers after reprogramming. (G) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in 2153L TAMs. (H) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in T12 TAMs. (I) Dot plot for Day 7 scRNAseq dataset showing STAT1 and SOCS1 expression enriched in the CXCL9+ Mo.Mac population. Created in BioRender. Zhao, N. (2026) https://BioRender.com/e6uqj0s .

    Techniques Used: Inhibition, Extraction, Flow Cytometry, Analysis, Quantitative Proteomics, Expressing, Western Blot, Marker, In Vitro

    Related Articles

    Incubation:

    Article Title: Exploring the immunomodulatory effects of environmental contaminants on autoimmune patients: An in vitro approach
    Article Snippet: Equal protein amounts were denatured, separated by 12 % SDS-PAGE, and transferred onto 0.45 μm PVDF membranes (Merck-Millipore, Burlington, MA, USA). .. Membranes were blocked with 5 % non-fat milk in TBS-T and incubated overnight at 4 °C with primary antibodies against phospho-AKT (Thr308), phospho-NFκB p65 (Ser536), phospho-p38 MAPK (Thr180/Tyr182), phospho-STAT1 (Tyr701), and phospho-STAT3 (Tyr705) (Cell Signaling Technology, Danvers, MA, USA; Santa Cruz Biotechnology, Dallas, TX, USA). .. Following washes, membranes were incubated with HRP-conjugated secondary antibodies, and signals were detected using PierceTM ECL substrate (Thermo Scientific, Waltham, MA, USA) on a ChemiDocTM MP imaging system (Bio-Rad, Hercules, CA, USA).

    FLAG-tag:

    Article Title: Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells.
    Article Snippet: Membranes were visualized using Clarity Western ECL Substrate (Bio-Rad, Cat# 1705061) and Bio-Rad ChemiDoc MP Imaging System, and analyzed using Bio-Rad ImageLab software. .. Primary antibodies included: YAP (D8H1X, Cell Signaling, #14074, 1:1,000), phospho-YAP Ser397 (D1E7Y, Cell Signaling, #13619, 1:1,000), phospho-LATS1 Ser909 (Cell Signaling, #9157, 1:1,000), LATS1 (C66B5, Cell Signaling, #3477, 1:1,000), LATS2 (D83D6, Cell Signaling, #5888, 1:1,000), phospho-MST1 Thr183/MST2 Thr180 (Cell Signaling, #49332, 1:1,000), MST1 (Cell Signaling, #14946, 1:1,000), JAK1 (Cell Signaling, #3344, 1:1,000), phospho-STAT1 Tyr701 (Cell Signaling, #9167, 1:1,000), STAT1 (Cell Signaling, #9172, 1:1,000), Flag Tag (ThermoFisher, Ref# MA1-91878, 1:2,000), P53 (Cell Signaling, #2527, 1:1,000), and β Actin (Santa Cruz, sc-47778, 1:1,000). .. Number of living cells was counted using trypan Blue Stain 0.4% (Gibco, Cat# 15250061).

    Cell-Signaling:

    Article Title: Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations
    Article Snippet: TBK1/NAK (D1B4) , Cell Signaling Technology , Cat #3504; RRID: AB_2255663. .. Phospho-Stat1 (Tyr701) , Cell Signaling Technology , Cat #7649; RRID: AB_10950970. .. Stat1 (D1K9Y) , Cell Signaling Technology , Cat #14994; RRID: AB_2737027.

    Western Blot:

    Article Title: DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling-Mediated Anti-tumor Immunity.
    Article Snippet: .. Western blot antibodies used in this study: DMAP1 (10411-1-AP), CDK4 (11026-1-AP), Cyclin E2 (85803-3-RR), PARP1 (13371-1-AP), GAPDH (60004-1-Ig), Vinculin (66305-1-Ig), β-Tubulin (66240-1- Ig), and β-Actin (66009-1-Ig) antibodies were from Proteintech; Phospho-Chk2 (Thr68) (HY-P80799), RPA32/RPA2 (HY-P80975), Chk1 (HY-P80082), and Chk2 (HY-P80083) antibodies were from MCE; Rad51 (F1110), CDK2 (F0022), CDK6 (F0372), Cyclin A2 (F1033), Cyclin B1 (F2522), Cyclin D1 (F2524), Phospho-CDK1 (Thr161) + CDK2/3 (Thr160) (F3185), Phospho-CDK1/2/3 (Thr14) (F2120), RPA-pS33 (F2375), MCM2 (F0581), and PCNA (F0018) antibodies were from Selleck; Phospho-Chk1 (Ser345) (2348), Phospho-ATM (Ser1981) (5883), Phospho-TBK1 (Ser172) (5483), TBK1 (38066), Phospho-STING (Ser365) (72971), STING (13647), Phospho-Stat1 (Tyr701) (9167), Stat1 (14994), Phospho-IRF-7 (Ser437/438) (24129), IRF-7 (72073), Phospho-IRF-3 (Ser396) (4947), IRF-3 (4302), HA-Tag (3724), MAR/PAR (89190), and Phospho-ATR (Ser428) (2853) antibodies were from CST; CDK1 (A11420) antibody and Rabbit control IgG (AC005) were from Abclonal; Phospho-CDK6 (Tyr24) (AF2440) and Phospho-CDK4 (Thr172) (AF8007) antibodies were from Affinity Biosciences; Goat Anti-Rabbit IgG-HRP (CW0103) and Goat Anti-Mouse IgG-HRP (CW0102) antibodies were from CWBIO. .. Reagents and chemicals used in this study inclu CldU (MCE, HY-112669), IdU (MCE, HY-B0307), Vadimezan (Selleck, S1537), Nelfinavir (TargetMol, T7779), AG99 (TargetMol, T5155), Nicardipine (TargetMol, T1215), Pantoprazole (TargetMol, T6928), Lidocaine (TargetMol, T1144), Fulvestrant (TargetMol, T2146), Dydrogesterone (TargetMol, T3036), Carbenoxolone (TargetMol, T0992), Metoprolol (TargetMol, T0487), Moxifloxacin (TargetMol, T0331L), Cilomilast (Selleck, S1455), Avasimibe (Selleck, S2187), and Dacinostat (TargetMol, T2454).

    Recombinase Polymerase Amplification:

    Article Title: DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling-Mediated Anti-tumor Immunity.
    Article Snippet: .. Western blot antibodies used in this study: DMAP1 (10411-1-AP), CDK4 (11026-1-AP), Cyclin E2 (85803-3-RR), PARP1 (13371-1-AP), GAPDH (60004-1-Ig), Vinculin (66305-1-Ig), β-Tubulin (66240-1- Ig), and β-Actin (66009-1-Ig) antibodies were from Proteintech; Phospho-Chk2 (Thr68) (HY-P80799), RPA32/RPA2 (HY-P80975), Chk1 (HY-P80082), and Chk2 (HY-P80083) antibodies were from MCE; Rad51 (F1110), CDK2 (F0022), CDK6 (F0372), Cyclin A2 (F1033), Cyclin B1 (F2522), Cyclin D1 (F2524), Phospho-CDK1 (Thr161) + CDK2/3 (Thr160) (F3185), Phospho-CDK1/2/3 (Thr14) (F2120), RPA-pS33 (F2375), MCM2 (F0581), and PCNA (F0018) antibodies were from Selleck; Phospho-Chk1 (Ser345) (2348), Phospho-ATM (Ser1981) (5883), Phospho-TBK1 (Ser172) (5483), TBK1 (38066), Phospho-STING (Ser365) (72971), STING (13647), Phospho-Stat1 (Tyr701) (9167), Stat1 (14994), Phospho-IRF-7 (Ser437/438) (24129), IRF-7 (72073), Phospho-IRF-3 (Ser396) (4947), IRF-3 (4302), HA-Tag (3724), MAR/PAR (89190), and Phospho-ATR (Ser428) (2853) antibodies were from CST; CDK1 (A11420) antibody and Rabbit control IgG (AC005) were from Abclonal; Phospho-CDK6 (Tyr24) (AF2440) and Phospho-CDK4 (Thr172) (AF8007) antibodies were from Affinity Biosciences; Goat Anti-Rabbit IgG-HRP (CW0103) and Goat Anti-Mouse IgG-HRP (CW0102) antibodies were from CWBIO. .. Reagents and chemicals used in this study inclu CldU (MCE, HY-112669), IdU (MCE, HY-B0307), Vadimezan (Selleck, S1537), Nelfinavir (TargetMol, T7779), AG99 (TargetMol, T5155), Nicardipine (TargetMol, T1215), Pantoprazole (TargetMol, T6928), Lidocaine (TargetMol, T1144), Fulvestrant (TargetMol, T2146), Dydrogesterone (TargetMol, T3036), Carbenoxolone (TargetMol, T0992), Metoprolol (TargetMol, T0487), Moxifloxacin (TargetMol, T0331L), Cilomilast (Selleck, S1455), Avasimibe (Selleck, S2187), and Dacinostat (TargetMol, T2454).

    Control:

    Article Title: DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling-Mediated Anti-tumor Immunity.
    Article Snippet: .. Western blot antibodies used in this study: DMAP1 (10411-1-AP), CDK4 (11026-1-AP), Cyclin E2 (85803-3-RR), PARP1 (13371-1-AP), GAPDH (60004-1-Ig), Vinculin (66305-1-Ig), β-Tubulin (66240-1- Ig), and β-Actin (66009-1-Ig) antibodies were from Proteintech; Phospho-Chk2 (Thr68) (HY-P80799), RPA32/RPA2 (HY-P80975), Chk1 (HY-P80082), and Chk2 (HY-P80083) antibodies were from MCE; Rad51 (F1110), CDK2 (F0022), CDK6 (F0372), Cyclin A2 (F1033), Cyclin B1 (F2522), Cyclin D1 (F2524), Phospho-CDK1 (Thr161) + CDK2/3 (Thr160) (F3185), Phospho-CDK1/2/3 (Thr14) (F2120), RPA-pS33 (F2375), MCM2 (F0581), and PCNA (F0018) antibodies were from Selleck; Phospho-Chk1 (Ser345) (2348), Phospho-ATM (Ser1981) (5883), Phospho-TBK1 (Ser172) (5483), TBK1 (38066), Phospho-STING (Ser365) (72971), STING (13647), Phospho-Stat1 (Tyr701) (9167), Stat1 (14994), Phospho-IRF-7 (Ser437/438) (24129), IRF-7 (72073), Phospho-IRF-3 (Ser396) (4947), IRF-3 (4302), HA-Tag (3724), MAR/PAR (89190), and Phospho-ATR (Ser428) (2853) antibodies were from CST; CDK1 (A11420) antibody and Rabbit control IgG (AC005) were from Abclonal; Phospho-CDK6 (Tyr24) (AF2440) and Phospho-CDK4 (Thr172) (AF8007) antibodies were from Affinity Biosciences; Goat Anti-Rabbit IgG-HRP (CW0103) and Goat Anti-Mouse IgG-HRP (CW0102) antibodies were from CWBIO. .. Reagents and chemicals used in this study inclu CldU (MCE, HY-112669), IdU (MCE, HY-B0307), Vadimezan (Selleck, S1537), Nelfinavir (TargetMol, T7779), AG99 (TargetMol, T5155), Nicardipine (TargetMol, T1215), Pantoprazole (TargetMol, T6928), Lidocaine (TargetMol, T1144), Fulvestrant (TargetMol, T2146), Dydrogesterone (TargetMol, T3036), Carbenoxolone (TargetMol, T0992), Metoprolol (TargetMol, T0487), Moxifloxacin (TargetMol, T0331L), Cilomilast (Selleck, S1455), Avasimibe (Selleck, S2187), and Dacinostat (TargetMol, T2454).



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    Image Search Results


    (A) Schematic of TAM extraction from murine TNBC tumors. (B) Flow cytometry analysis gating strategy comparing CXCL9 protein abundance captured in the media. (C) Flow cytometry analysis gating for CD11b+F4/80+ cells after culture. (D) Bar plots summarize flow cytometry across replicates for CXCL9 abundance in media (T-test, p < 0.001, n=3, SEM bars) (E) Bar plots summarize flow cytometry across replicates for CXCL9 and iNOS within TAMs. (One way ANOVA, p < 0.001 for all comparisons, n=6, SEM bars) (F) Schematic of TAM expression of markers after reprogramming. (G) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in 2153L TAMs. (H) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in T12 TAMs. (I) Dot plot for Day 7 scRNAseq dataset showing STAT1 and SOCS1 expression enriched in the CXCL9+ Mo.Mac population. Created in BioRender. Zhao, N. (2026) https://BioRender.com/e6uqj0s .

    Journal: Cancer immunology research

    Article Title: MERTK inhibition cooperates with immunomodulatory cyclophosphamide to induce CXCL9 + monocyte-macrophage programming and durable antitumor immunity in triple negative breast cancer

    doi: 10.1158/2326-6066.CIR-26-0278

    Figure Lengend Snippet: (A) Schematic of TAM extraction from murine TNBC tumors. (B) Flow cytometry analysis gating strategy comparing CXCL9 protein abundance captured in the media. (C) Flow cytometry analysis gating for CD11b+F4/80+ cells after culture. (D) Bar plots summarize flow cytometry across replicates for CXCL9 abundance in media (T-test, p < 0.001, n=3, SEM bars) (E) Bar plots summarize flow cytometry across replicates for CXCL9 and iNOS within TAMs. (One way ANOVA, p < 0.001 for all comparisons, n=6, SEM bars) (F) Schematic of TAM expression of markers after reprogramming. (G) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in 2153L TAMs. (H) Western blot analysis comparing STAT, MAPK, and TAM marker expression changes across in vitro treatments in T12 TAMs. (I) Dot plot for Day 7 scRNAseq dataset showing STAT1 and SOCS1 expression enriched in the CXCL9+ Mo.Mac population. Created in BioRender. Zhao, N. (2026) https://BioRender.com/e6uqj0s .

    Article Snippet: Blots were blocked with 5% non-fat dry milk (BioRad, 1706404) in PBS, then probed with the following antibodies in 5% BSA (Sigma-Aldrich, A7906) solution: MERTK (Cell Signaling Technology (CST), 38102), AXL (CST, 8661, RRID:AB_11217435), p44/42 (CST, 9102, RRID:AB_330744), p-p44/42 (CST, 9101, RRID:AB_331646), iNOS (CST, 13120, RRID:AB_2799268), PD-L1 (R&D Systems, AF1019, RRID:AB_354540), p-STAT1 (CST, 8062, RRID:AB_10949108), Arg1(CST, 93668, RRID:AB_2800207), and SOCS1 (CST, 55313).

    Techniques: Inhibition, Extraction, Flow Cytometry, Analysis, Quantitative Proteomics, Expressing, Western Blot, Marker, In Vitro

    Modulation of intracellular signaling pathways in HD, RA, and SLE cells exposed to environmental contaminants. Heatmap showing the relative expression and phosphorylation levels of key signaling proteins involved in immune regulation, inflammation, and cell survival (STAT1, STAT3, p38, AKT, and NFκB) and their phosphorylated forms in HD, RA, and SLE after exposure to PM, silica, and TCDD. Data are represented as z-score normalized values. Asterisks indicate statistically significant differences compared with the unstimulated control within each group (p < 0.05). AKT: protein kinase B; HD: healthy donors; NFκB: nuclear factor kappa-light-chain-enhancer of activated B cells; P: phosphorylated form; p38: p38 mitogen-activated protein kinase; PM: particulate matter; RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; STAT: signal transducer and activator of transcription; TCDD: 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    Journal: Journal of Translational Autoimmunity

    Article Title: Exploring the immunomodulatory effects of environmental contaminants on autoimmune patients: An in vitro approach

    doi: 10.1016/j.jtauto.2025.100341

    Figure Lengend Snippet: Modulation of intracellular signaling pathways in HD, RA, and SLE cells exposed to environmental contaminants. Heatmap showing the relative expression and phosphorylation levels of key signaling proteins involved in immune regulation, inflammation, and cell survival (STAT1, STAT3, p38, AKT, and NFκB) and their phosphorylated forms in HD, RA, and SLE after exposure to PM, silica, and TCDD. Data are represented as z-score normalized values. Asterisks indicate statistically significant differences compared with the unstimulated control within each group (p < 0.05). AKT: protein kinase B; HD: healthy donors; NFκB: nuclear factor kappa-light-chain-enhancer of activated B cells; P: phosphorylated form; p38: p38 mitogen-activated protein kinase; PM: particulate matter; RA: rheumatoid arthritis; SLE: systemic lupus erythematosus; STAT: signal transducer and activator of transcription; TCDD: 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    Article Snippet: Membranes were blocked with 5 % non-fat milk in TBS-T and incubated overnight at 4 °C with primary antibodies against phospho-AKT (Thr308), phospho-NFκB p65 (Ser536), phospho-p38 MAPK (Thr180/Tyr182), phospho-STAT1 (Tyr701), and phospho-STAT3 (Tyr705) (Cell Signaling Technology, Danvers, MA, USA; Santa Cruz Biotechnology, Dallas, TX, USA).

    Techniques: Protein-Protein interactions, Expressing, Phospho-proteomics, Control